Nucleotide sequence and expression of the human skeletal alpha-actin gene: evolution of functional regulatory domains.

Abstract

Regulation of the actin multigene family involves the recognition of regulatory sequences that specify the tissue type and developmental program of expression for each actin isotype. In order to investigate the underlying regulatory mechanisms, the human skeletal alpha-actin gene and its 5' regulatory region have been cloned and sequenced. This actin gene… (More)

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