Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5

@article{Meyer2007NucleotideRB,
  title={Nucleotide recognition by the cytoplasmic domain of the human chloride transporter ClC-5},
  author={Sebastian Meyer and Sara Savaresi and Ian Cameron Forster and Raimund Dutzler},
  journal={Nature Structural &Molecular Biology},
  year={2007},
  volume={14},
  pages={60-67}
}
The ubiquitous CBS domains, which are found as part of cytoplasmic domains in the ClC family of chloride channels and transporters, have previously been identified as building blocks for regulatory nucleotide-binding sites. Here we report the structures of the cytoplasmic domain of the human transporter ClC-5 in complex with ATP and ADP. The nucleotides bind to a specific site in the protein. As determined by equilibrium dialysis, the affinities for ATP, ADP and AMP are in the high micromolar… CONTINUE READING
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