Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.

@article{Braganhol2015NucleotideRC,
  title={Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells.},
  author={Elizandra Braganhol and Filip Kukulski and Sebastien Levesque and Michel Fausther and {\'E}lise G. Lavoie and Alfeu Zanotto-Filho and Let{\'i}cia Scussel Bergamin and Julie Pelletier and Fariborz Bahrami and Fethia Ben Yebdri and Jos{\'e} Cl{\'a}udio Fonseca Moreira and Ana Maria Oliveira Battastini and Jean S{\'e}vigny},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1852 1},
  pages={120-30}
}
Glioma cells release cytokines to stimulate inflammation that facilitates cell proliferation. Here, we show that Lipopolysaccharide (LPS) treatment could induce glioma cells to proliferate and this process was dependent on nucleotide receptor activation as well as interleukin-8 (IL-8/CXCL8) secretion. We observed that extracellular nucleotides controlled IL-8/CXCL8 and monocyte chemoattractant protein 1 (MCP-1/CCL2) release by U251MG and U87MG human glioma cell lines via P2X7 and P2Y6 receptor… CONTINUE READING