Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster

@article{Kreitman1983NucleotidePA,
  title={Nucleotide polymorphism at the alcohol dehydrogenase locus of Drosophila melanogaster},
  author={M. Kreitman},
  journal={Nature},
  year={1983},
  volume={304},
  pages={412-417}
}
The sequencing of eleven cloned Drosophila melanogaster alcohol dehydrogenase (Adh) genes from five natural populations has revealed a large number of previously hidden polymorphisms. Only one of the 43 polymorphisms results in an amino acid change, the one responsible for the two electrophoretic variants (fast, Adh-f, and slow, Adh-s) found in nearly all natural populations. The implication is that most amino acid changes in Adh would be selectively deleterious. 
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The population genetics of alcohol dehydrogenase activity in Drosophila melanogaster
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Conservation and change in the DNA sequences coding for alcohol dehydrogenase in sibling species of Drosophila
The DNA sequences of the alcohol dehydrogenase (Adh) genes of four very closely related species of Drosophila show that the rates of nucleotide change vary greatly in different functional domains ofExpand
Adh Nucleotide Variation in Drosophila willistoni: High Replacement Polymorphism in an Electrophoretically Monomorphic Protein
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DNA sequence analysis of 18 alleles throughout the distribution of the species has revealed six replacement polymorphisms and the ratio of replacement to silent polymorphisms is higher in D. willistoni than in any other Drosophila species studied for Adh nucleotide variation. Expand
Allele-specific population structure of Drosophila melanogaster alcohol dehydrogenase at the molecular level.
TLDR
The results suggest that the current range of Fast and In(2L)t Slow haplotypes is recent and that an older genetic differentiation between populations was followed by allele-specific gene flow. Expand
Molecular analysis of a spontaneous insertion mutation near the alcohol dehydrogenase gene of Drosophila melanogaster.
The structural integrity of the Adh gene in several isogenic lines of Drosophila melanogaster was tested by Southern blot analysis using a 4.75 kilobase (kb) genomic clone of Alcohol dehydrogenaseExpand
Molecular population genetics of an electrophoretically monomorphic protein in the alcohol dehydrogenase region of Drosophila pseudoobscura.
TLDR
The results suggest that the ADH enzyme of D. pseudoobscura lacks amino acid polymorphisms because theneutral mutation rate of nonsynonymous sites is low, and the neutral mutation parameter for synonymous sites is heterogeneous between domains of the Adh region. Expand
Dehydrogenase Locus in the
Sequence variation among 10 alleles of the alcohol dehydrogenase (Adh) gene of the Hawaiian drosophilid D. mimica was analyzed with reference to the evolutionary history of the Hawaiian subgroup asExpand
An association between ADH protein levels and polymorphic nucleotide variation in the Adh gene of Drosophila melanogaster.
TLDR
Southern analysis of the Adh region of 212 Drosophila melanogaster lines collected from the Tahbilk winery revealed linkage disequilibrium between a 37-bp insertion and the fast electrophoretic variant of alcohol dehydrogenase (ADH-F), suggesting that either polymorphic nucleotide-site variants positively associated with delta 2 on the second chromosome or delta 2 itself increases larval levels of ADH protein. Expand
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