Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages

@inproceedings{Jurez2014NucleotideoligomerizingD,
  title={Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages},
  author={Esmeralda Ju{\'a}rez and Claudia Carranza and Fernando Hern{\'a}ndez-S{\'a}nchez and E. A. Loyola and Dante Escobedo and Juan Carlos Le{\'o}n-Contreras and Rogelio E Hern{\'a}ndez-Pando and Martha Bucio Torres and Eduardo Sada},
  booktitle={BMC pulmonary medicine},
  year={2014}
}
BACKGROUND Nucleotide-binding oligomerizing domain-1 (NOD1) is a cytoplasmic receptor involved in recognizing bacterial peptidoglycan fragments that localize to the cytosol. NOD1 activation triggers inflammation, antimicrobial mechanisms and autophagy in both epithelial cells and murine macrophages. NOD1 mediates intracellular pathogen clearance in the lungs of mice; however, little is known about NOD1's role in human alveolar macrophages (AMs) or its involvement in Mycobacterium tuberculosis… CONTINUE READING
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