Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells.

@article{Kemp2004NucleotidemediatedMS,
  title={Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells.},
  author={P. Auffret van der Kemp and Rosemary A Sugar and Alan D Jackson},
  journal={American journal of respiratory cell and molecular biology},
  year={2004},
  volume={31 4},
  pages={446-55}
}
Most current cell-based models for examining the regulation of mucin secretion demonstrate low signal-to-noise ratios, making experimental manipulation and data interpretation difficult. Using adenosine triphosphate (ATP) as a mucin secretagogue, we have developed a model of agonist-induced mucin secretion in differentiated human bronchial epithelial cells. Mucin secretory signals were estimated using enzyme-linked lectin assay, and typical signals of 300-400% of baseline were observed in… CONTINUE READING
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