Nucleotide identification and orientation discrimination of DNA homopolymers immobilized in a protein nanopore.

@article{Purnell2008NucleotideIA,
  title={Nucleotide identification and orientation discrimination of DNA homopolymers immobilized in a protein nanopore.},
  author={Robert F Purnell and Kunal K. Mehta and Jacob J. Schmidt},
  journal={Nano letters},
  year={2008},
  volume={8 9},
  pages={3029-34}
}
Nanopores have been used as extremely sensitive resistive pulse sensors to detect analytes at the molecular level. There has been interest in using such a scheme to rapidly and inexpensively sequence single molecules of DNA. To establish reference current levels for adenine, cytosine, and thymine nucleotides, we measured the blockage currents following immobilization of single-stranded DNA polyadenine, polycytosine, and polythymine within a protein nanopore in chemical orientations in which… CONTINUE READING
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