Nucleotide excision repair polymorphisms and survival outcome for patients with metastatic breast cancer

@article{Bewick2010NucleotideER,
  title={Nucleotide excision repair polymorphisms and survival outcome for patients with metastatic breast cancer},
  author={Mary A. Bewick and Robert M Lafrenie and Michael Sc Conlon},
  journal={Journal of Cancer Research and Clinical Oncology},
  year={2010},
  volume={137},
  pages={543-550}
}
PurposeInter-individual variations in treatment efficacy may be influenced by polymorphisms in DNA repair genes. We investigated the association of 3 functional polymorphisms in the nucleotide excision repair (NER) pathway with survival outcome of 95 patients with metastatic breast cancer (MBC) treated with DNA-damaging chemotherapy.MethodsERCC1 8092 C/A, ERCC2 Asp312Asn and ERCC2 Lys751Gln were determined using Taqman-based genotyping assays. Genotype associations with breast cancer-specific… CONTINUE READING

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