Nucleotide excision repair is impaired by binding of transcription factors to DNA

@article{Sabarinathan2016NucleotideER,
  title={Nucleotide excision repair is impaired by binding of transcription factors to DNA},
  author={Radhakrishnan Sabarinathan and Loris Mularoni and Jordi Deu-Pons and Abel Gonzalez-Perez and N{\'u}ria L{\'o}pez-Bigas},
  journal={Nature},
  year={2016},
  volume={532},
  pages={264-267}
}
Somatic mutations are the driving force of cancer genome evolution. The rate of somatic mutations appears to be greatly variable across the genome due to variations in chromatin organization, DNA accessibility and replication timing. However, other variables that may influence the mutation rate locally are unknown, such as a role for DNA-binding proteins… CONTINUE READING