Nucleotide excision repair in differentiated cells.

  title={Nucleotide excision repair in differentiated cells.},
  author={Caroline G C van der Wees and Jacob G. Jansen and Harry Vrieling and Arnoud van der Laarse and Albert A. van Zeeland and L. H. Mullenders},
  journal={Mutation research},
  volume={614 1-2},
Nucleotide excision repair (NER) is the principal pathway for the removal of a wide range of DNA helix-distorting lesions and operates via two NER subpathways, i.e. global genome repair (GGR) and transcription-coupled repair (TCR). Although detailed information is available on expression and efficiency of NER in established mammalian cell lines, little is known about the expression of NER pathways in (terminally) differentiated cells. The majority of studies in differentiated cells have focused… CONTINUE READING


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