Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer.

@article{Gu2005NucleotideER,
  title={Nucleotide excision repair gene polymorphisms and recurrence after treatment for superficial bladder cancer.},
  author={Jian T Gu and Hua Zhao and Colin P. N. Dinney and Yong Zhu and Dan Leibovici and Carlos E Bermejo and Herbert Barton Grossman and X ianchao Wu},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2005},
  volume={11 4},
  pages={1408-15}
}
PURPOSE Interindividual differences in DNA repair capacity not only modify individual susceptibility to carcinogenesis, but also affect individual response to cancer treatment. Nucleotide excision repair (NER) is one of the major DNA repair pathways in mammalian cells involved in the removal of a wide variety of DNA lesions. Polymorphisms in NER genes may influence DNA repair capacity and affect clinical outcome of bladder cancer treatment. EXPERIMENTAL DESIGN To test the influence of NER… CONTINUE READING