Nucleotide-evoked calcium signals and anion secretion in equine cultured epithelia that express apical P2Y2 receptors and pyrimidine nucleotide receptors.

@article{Wilson1998NucleotideevokedCS,
  title={Nucleotide-evoked calcium signals and anion secretion in equine cultured epithelia that express apical P2Y2 receptors and pyrimidine nucleotide receptors.},
  author={Stuart Mark Wilson and Vivian Law and John D. Pediani and Elizabeth Anne Allen and Guinn Wilson and Zara E Khan and Wing Hung Ko},
  journal={British journal of pharmacology},
  year={1998},
  volume={124 4},
  pages={832-8}
}
1. Experiments with a spontaneously transformed equine epithelial cell line showed that certain nucleotides increased intracellular free calcium ([Ca2+]i) in cells plated on glass coverslips. The rank order of potency was ATP UTP > 5-Br-UTP, whilst UDP and ADP were ineffective. The response thus appears to be mediated by P2Y2 receptors. 2. Nucleotides also increased short circuit current (Isc) in cells grown into epithelial monolayers and the rank order of potency was UDP> UTP > 5-Br-UTP > ATP… CONTINUE READING

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