Nucleotide divergences in the core promoter and precore region of genotype D hepatitis B virus in patients with persistently elevated or normal ALT levels.

@article{Bozdayi2001NucleotideDI,
  title={Nucleotide divergences in the core promoter and precore region of genotype D hepatitis B virus in patients with persistently elevated or normal ALT levels.},
  author={Abdurrahman Mithat Bozdayi and Hakan Bozkaya and Ahmet Reşat T{\"u}rkyilmaz and M Sar{\'y}odlu and H{\"u}lya Çetinkaya and Selim Karayalçin and Cihan Yurdaydin and Ozden Uzunalimoğlu},
  journal={Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology},
  year={2001},
  volume={21 1},
  pages={91-101}
}
BACKGROUND Mutation in the hepatitis B virus precore codon 28, creating a translational stop codon and double 1762-1764 T/A mutations in the core promoter region, controlling the transcription of the precore RNA and the core RNA have been suggested to correlate with the HBeAg status of patients with HBV infection. OBJECTIVES The aim of the study was to further investigate the association of nucleotide divergences in both core promoter and precore regions with liver cell injury (reflected by… CONTINUE READING

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