Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase.

@article{Farrow1999NucleotideDF,
  title={Nucleotide determinants for tRNA-dependent amino acid discrimination by a class I tRNA synthetase.},
  author={Mark A. Farrow and Brian E Nordin and Paul R. Schimmel},
  journal={Biochemistry},
  year={1999},
  volume={38 51},
  pages={16898-903}
}
The high accuracy of the genetic code relies on the ability of tRNA synthetases to discriminate rigorously between closely similar amino acids. While the enzymes can detect differences between closely similar amino acids at an accuracy of about 1 part in 100-200, a finer discrimination requires the presence of the cognate tRNA. The role of the tRNA is to… CONTINUE READING