Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase*

  title={Nucleotide-dependent Domain Movement in the ATPase Domain of a Human Type IIA DNA Topoisomerase*},
  author={Hua Wei and Alexander J. Ruthenburg and Seth K. Bechis and Gregory L. Verdine},
  journal={Journal of Biological Chemistry},
  pages={37041 - 37047}
Type IIA DNA topoisomerases play multiple essential roles in the management of higher-order DNA structure, including modulation of topological state, chromosome segregation, and chromatin condensation. These diverse physiologic functions are all accomplished through a common molecular mechanism, wherein the protein catalyzes transient cleavage of a DNA duplex (the G-segment) to yield a double-stranded gap through which another duplex (the T-segment) is passed. The overall process is… 

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