Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon.

@article{Faye2013NucleotideCO,
  title={Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon.},
  author={Mame Daro Faye and Tyson Ernst Graber and Peng Liu and Nehal S. Thakor and Stephen D. Baird and Danielle Durie and Martin Holcik},
  journal={Molecular and cellular biology},
  year={2013},
  volume={33 2},
  pages={307-18}
}
The vast majority of cellular mRNAs initiate their translations through a well-defined mechanism of ribosome recruitment that occurs at the 5'-terminal 7-methylguanosine cap with the help of several canonical protein factors. A subset of cellular and viral mRNAs contain regulatory motifs in their 5' untranslated regions (UTRs), termed internal ribosome entry sites (IRES), that sidestep this canonical mode of initiation. On cellular mRNAs, this mechanism requires IRES trans-acting protein… CONTINUE READING

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