Nucleotide changes in the translated region of SCN5A from Japanese patients with Brugada syndrome and control subjects.

@article{Takahata2003NucleotideCI,
  title={Nucleotide changes in the translated region of SCN5A from Japanese patients with Brugada syndrome and control subjects.},
  author={Takenori Takahata and norio Yasui-Furukori and Shingo Sasaki and Tomonori Igarashi and Ken Okumura and Akihiro Munakata and Tomonori Tateishi},
  journal={Life sciences},
  year={2003},
  volume={72 21},
  pages={
          2391-9
        }
}
The mutations of the SCN5A gene have been implicated to play a pathogenetic role in Brugada syndrome, which causes ventricular fibrillation. To determine the Brugada-associated mutations in Japanese patients, facilitate pre-symptomatic diagnosis, and allow genotype-phenotype studies, we screened unrelated patients with Brugada syndrome for mutations. DNAs from 6 Japanese patients were obtained and the sequence in the translated region of SCN5A was determined. We could not find the mutations… CONTINUE READING
BETA

Topics from this paper.

Similar Papers

Citations

Publications citing this paper.
SHOWING 1-10 OF 12 CITATIONS

Genetic analysis of the cardiac sodium channel gene SCN5A in Koreans with Brugada syndrome

  • Journal of Human Genetics
  • 2004
VIEW 3 EXCERPTS
CITES BACKGROUND & RESULTS
HIGHLY INFLUENCED