Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense.

@article{Franchi2006NucleotidebindingOD,
  title={Nucleotide-binding oligomerization domain-like receptors: intracellular pattern recognition molecules for pathogen detection and host defense.},
  author={Luigi Franchi and Christine McDonald and Thirumala-Devi Kanneganti and A. Amer and Gabriel N{\'u}{\~n}ez},
  journal={Journal of immunology},
  year={2006},
  volume={177 6},
  pages={3507-13}
}
The nucleotide binding oligomerization domain-like receptor (NLR) family of pattern recognition molecules is involved in a diverse array of processes required for host immune responses against invading pathogens. Unlike TLRs that mediate extracellular recognition of microbes, several NLRs sense pathogens in the cytosol and upon activation induce host… CONTINUE READING