Nucleotide analogue inhibitors of purine nucleoside phosphorylase.

  title={Nucleotide analogue inhibitors of purine nucleoside phosphorylase.},
  author={Thomas A. Krenitsky and Joel V. Tuttle and Wayne H. Miller and Allan R. Moorman and G Faye Orr and Lilia Beauchamp},
  journal={The Journal of biological chemistry},
  volume={265 6},
The diphosphate of the antiherpetic agent acyclovir [9-[(2-hydroxyethoxy)methyl]guanine] has been shown to inhibit purine nucleoside phosphorylase with unique potency (Tuttle, J. V., and Krenitsky, T. A. (1984) J. Biol. Chem. 259, 4065-4069). A major factor contributing to the superior inhibition by this diphosphate over the corresponding mono- and triphosphates is revealed here. Homologues of acyclovir mono- and diphosphate that extend the ethoxy moiety by one to four methylene groups were… CONTINUE READING
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hp://w w w D ow nladed from 3068 CH2-0-C&-(CH,).--O-R R Compound No. 4-i -P03H2 -P03tiP03ti2 -P03HP03HP03Hz na nb nc nd by gest on Sptem er 13

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