Nucleotide Sequence Variation within the PI3K p85 Alpha Gene Associates with Alcohol Risk Drinking Behaviour in Adolescents

@article{Desrivires2008NucleotideSV,
  title={Nucleotide Sequence Variation within the PI3K p85 Alpha Gene Associates with Alcohol Risk Drinking Behaviour in Adolescents},
  author={Sylvane Desrivi{\`e}res and Kristina Krause and Anne Marie Dyer and Josef Frank and Dorothea Blomeyer and Mark Lathrop and Karl J Mann and Tobias Banaschewski and Manfred Laucht and Gunter Schumann},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={714 - 719}
}
BACKGROUND While the phosphatidylinositol 3-kinase (PI3K)-dependent signaling pathway is typically known to regulate cell growth and survival, emerging evidence suggest a role for this pathway in regulating the behavioural responses to addictive drugs. METHODOLOGY/PRINCIPAL FINDINGS To investigate whether PI3K contributes to patterns of risky alcohol drinking in human, we investigated genetic variations in PIK3R1, encoding the 85 kD regulatory subunit of PIK, in 145 family trios consisting of… CONTINUE READING

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Binge drinking upregulates accumbens mGluR5-Homer2-PI3K signaling: functional implications for alcoholism.

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CITES BACKGROUND
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