Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells.

@article{Buvinic2007NucleotidePR,
  title={Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells.},
  author={Sonja Buvinic and Marcela Bravo-Zehnder and Jos{\'e} Luis Boyer and Juan Pablo Huidobro-Toro and Alfonso Gonz{\'a}lez},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 24},
  pages={4289-301}
}
Epidermal growth factor receptor (EGFR) function is transregulated by a variety of stimuli, including agonists of certain G-protein-coupled receptors (GPCRs). One of the most ubiquitous GPCRs is the P2Y(1) receptor (P2RY1, hereafter referred to as P2Y(1)R) for extracellular nucleotides, mainly ADP. Here, we show in tumoral HeLa cells and normal FRT epithelial cells that P2Y(1)R broadcasts mitogenic signals by transactivating the EGFR. The pathway involves PKC, Src and cell surface… CONTINUE READING