Nucleostemin mRNA is expressed in both normal and malignant renal tissues

@article{Fan2006NucleosteminMI,
  title={Nucleostemin mRNA is expressed in both normal and malignant renal tissues},
  author={Yang Yi Fan and Zong-chao Liu and S Zhao and Fang Lou and Staffan Nilsson and Peter Ekman and Deng-fei Xu and Xiefan Fang},
  journal={British Journal of Cancer},
  year={2006},
  volume={94},
  pages={1658 - 1662}
}
Nucleostemin (NS), a p53-binding protein, has been shown essential for stem and cancer cell proliferation and implicated in oncogenesis. To explore potential contributions of NS to the development of clear cell renal cell carcinomas (ccRCCs), we determined NS expression in ccRCC cell lines, and in paired normal and malignant renal tissues from 31 patients with ccRCC. Nucleostemin mRNA and/or protein expression was observed in all four cell lines and 27 of 31 (87%) tumour specimens. Surprisingly… CONTINUE READING

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