Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis.

@article{Mjelle2007NucleosomesPA,
  title={Nucleosomes possess a high affinity for glomerular laminin and collagen IV and bind nephritogenic antibodies in murine lupus-like nephritis.},
  author={Janne Erikke Mjelle and Ole Petter Rekvig and Kristin A Fenton},
  journal={Annals of the rheumatic diseases},
  year={2007},
  volume={66 12},
  pages={1661-8}
}
AIM Lupus nephritis is closely associated with in vivo autoantibody-binding to glomerular membrane-associated electron-dense structures (EDS). The biochemical nature and cellular origin of EDS are controversial, and definitive characterisation needs to be performed. METHODS By using the terminal transferase biotin-dUTP nick end-labelling (TUNEL) assay at… CONTINUE READING