Nucleosomes positioned by ORC facilitate the initiation of DNA replication.

  title={Nucleosomes positioned by ORC facilitate the initiation of DNA replication.},
  author={James R Lipford and Stephen P Bell},
  journal={Molecular cell},
  volume={7 1},
The packaging of eukaryotic DNA into nucleosomes is a critical regulator of nuclear events. To address the interplay between chromatin and replication initiation, we have assessed the determinants and function of the nucleosomal configuration of S. cerevisiae replication origins. Using in vitro and in vivo assays, we demonstrate that the yeast initiator, the origin recognition complex (ORC), is required to maintain the nucleosomal configuration adjacent to origins. Disruption of the ORC… CONTINUE READING
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