Nucleosomes facilitate their own invasion

@article{Li2004NucleosomesFT,
  title={Nucleosomes facilitate their own invasion},
  author={Gu Li and Jonathan Widom},
  journal={Nature Structural & Molecular Biology},
  year={2004},
  volume={11},
  pages={763-769}
}
DNA wrapped in nucleosomes is sterically occluded, creating obstacles for polymerase, regulatory, remodeling, repair and recombination complexes, which require access to the wrapped DNA. How such complexes recognize and gain access to their DNA target sites is not known. Here we report the direct detection of a dynamic equilibrium conformational transition in nucleosomes that greatly increases the distance between the end of the nucleosomal DNA and the histone core. We quantified the… CONTINUE READING

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