Nucleosomes are exposed at the cell surface in apoptosis.

  title={Nucleosomes are exposed at the cell surface in apoptosis.},
  author={Marko Z. Radic and Tony Norman Marion and Marc Monestier},
  journal={Journal of immunology},
  volume={172 11},
Apoptotic cells are considered the source of DNA, histones, and nucleoprotein complexes that drive the production of autoantibodies in systemic lupus erythematosus. However, the role of apoptotic cells in the activation of the immune system is not clear. To explore interactions that may initiate or sustain the production of anti-nuclear autoantibodies, we characterized the binding of a large panel of monoclonal autoantibodies to apoptotic cells. Autoantibodies to DNA, individual core histones… CONTINUE READING


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