Nucleosomes are depleted at the VSG expression site transcribed by RNA polymerase I in African trypanosomes.

Abstract

In most eukaryotes, RNA polymerase I (Pol I) exclusively transcribes long arrays of identical rRNA genes (ribosomal DNA [rDNA]). African trypanosomes have the unique property of using Pol I to also transcribe the variant surface glycoprotein VSG genes. VSGs are important virulence factors because their switching allows trypanosomes to escape the host immune… (More)
DOI: 10.1128/EC.00282-09

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