Nucleosomes and regulation of gene expression. Structure of the HIV-1 5'LTR.

@article{Widak1998NucleosomesAR,
  title={Nucleosomes and regulation of gene expression. Structure of the HIV-1 5'LTR.},
  author={Piotr Widłak and William Garrard},
  journal={Acta biochimica Polonica},
  year={1998},
  volume={45 1},
  pages={209-19}
}
Packaging of DNA into chromatin adds complexity to the problem of regulation of gene expression. Nucleosomes affect the accessibility of transcription factors to occupy their binding sites in chromatin of eukaryotic cells. The disruption of nucleosome structure within the enhancer/promoter region of the integrated HIV-1 proviral genome is an instructive example of a chromatin remodeling process during transcriptional activation. To investigate the mechanism responsible for generating nuclease… CONTINUE READING