Nucleosomes and neutrophil activation in sickle cell disease painful crisis.

  title={Nucleosomes and neutrophil activation in sickle cell disease painful crisis.},
  author={Marein Schimmel and E. Mohammed Nur and Bart J. Biemond and Gerard J van Mierlo and Shabnam Solati and Desiderius P. M. Brandjes and H M Otten and J. B. Schnog and Sacha Zeerleder},
  volume={98 11},
Activated polymorphonuclear neutrophils play an important role in the pathogenesis of vaso-occlusive painful sickle cell crisis. Upon activation, polymorphonuclear neutrophils can form neutrophil extracellular traps. Neutrophil extracellular traps consist of a meshwork of extracellular DNA, nucleosomes, histones and neutrophil proteases. Neutrophil extracellular traps have been demonstrated to be toxic to endothelial and parenchymal cells. This prospective cohort study was conducted to… CONTINUE READING

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