• Corpus ID: 238634445

Nucleosome sliding can influence the spreading of histone modifications

  title={Nucleosome sliding can influence the spreading of histone modifications},
  author={Shantanu Kadam and Tripti Bameta and Ranjith Padinhateeri},
Nucleosomes are the fundamental building blocks of chromatin that not only help in the folding of chromatin but also in carrying epigenetic information. It is known that nucleosome sliding is responsible for dynamically organizing chromatin structure and the resulting gene regulation. Since sliding can move two neighboring nucleosomes physically close or away, can it play a role in the spreading of histone modifications ? We investigate this by simulating a stochastic model that couples… 

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