Nucleosome positioning in human HOX gene clusters.

  title={Nucleosome positioning in human HOX gene clusters.},
  author={Peter V. Kharchenko and Caroline J Woo and Michael Y. Tolstorukov and Robert E. Kingston and Peter J. Park},
  journal={Genome research},
  volume={18 10},
The distribution of nucleosomes along the genome is a significant aspect of chromatin structure and is thought to influence gene regulation through modulation of DNA accessibility. However, properties of nucleosome organization remain poorly understood, particularly in mammalian genomes. Toward this goal we used tiled microarrays to identify stable nucleosome positions along the HOX gene clusters in human cell lines. We show that nucleosome positions exhibit sequence properties and long-range… CONTINUE READING