Nucleosome mobilization catalysed by the yeast SWI/SNF complex

@article{Whitehouse1999NucleosomeMC,
  title={Nucleosome mobilization catalysed by the yeast SWI/SNF complex},
  author={Iestyn Whitehouse and Andrew Flaus and Bradley R. Cairns and Malcolm F. White and Jerry L. Workman and Tom Owen-Hughes},
  journal={Nature},
  year={1999},
  volume={400},
  pages={784-787}
}
The generation of a local chromatin topology conducive to transcription is a key step in gene regulation. The yeast SWI/SNF complex is the founding member of a family of ATP-dependent remodelling activities capable of altering chromatin structure both in vitro and in vivo. Despite its importance, the pathway by which the SWI/SNF complex disrupts chromatin structure is unknown. Here we use a model system to demonstrate that the yeast SWI/SNF complex can reposition nucleosomes in an ATP-dependent… 
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It is shown that hSWI-SNF and its ATPases have the ability to transfer histone octamers from donor nucleosomes to acceptor DNA and the ability of the isolated ATPase subunits to catalyze these reactions suggests that these subunits play a key role in determining the mechanistic capabilities of the SWI- SNF family of remodeling complexes.
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TLDR
It is found that the SWI/SNF remodeling reaction on a nucleosome array is a highly reversible process, which suggests that recovery from SWI /SNF action involves interactions among nucleosomes.
Persistent Site-Specific Remodeling of a Nucleosome Array by Transient Action of the SWI/SNF Complex
TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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