Nucleosome dynamics regulates DNA processing

Abstract

DSBs, if not repaired properly, pose a serious threat to genome integrity. Improperly repaired DSBs can lead to loss of genetic material, to chromosomal duplications or translocations and to carcinogenesis1. The yeast Mre11–Rad50–Xrs2 (MRX) complex facilitates the recognition of DNA ends and commitment to repair by homologous recombination. Subsequently… (More)

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