Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair.

@article{Odell2011NucleosomeDB,
  title={Nucleosome disruption by DNA ligase III-XRCC1 promotes efficient base excision repair.},
  author={Ian D. Odell and Joy-El R Barbour and Drew L Murphy and Julie Della-Maria and Joann Balazs Sweasy and Alan E Tomkinson and Susan S. Wallace and David S. Pederson},
  journal={Molecular and cellular biology},
  year={2011},
  volume={31 22},
  pages={
          4623-32
        }
}
Each day, approximately 20,000 oxidative lesions form in the DNA of every nucleated human cell. The base excision repair (BER) enzymes that repair these lesions must function in a chromatin milieu. We have determined that the DNA glycosylase hNTH1, apurinic endonuclease (APE), and DNA polymerase β (Pol β), which catalyze the first three steps in BER, are able to process their substrates in both 601- and 5S ribosomal DNA (rDNA)-based nucleosomes. hNTH1 formed a discrete ternary complex that was… CONTINUE READING

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