Nucleosome disruption at the yeast PHO5 promoter upon PHO5 induction occurs in the absence of DNA replication

@article{Schmid1992NucleosomeDA,
  title={Nucleosome disruption at the yeast PHO5 promoter upon PHO5 induction occurs in the absence of DNA replication},
  author={Andrea N. Schmid and K D Fascher and Wolfram Hoerz},
  journal={Cell},
  year={1992},
  volume={71},
  pages={853-864}
}
Activation of the PHO5 gene in S. cerevisiae by phosphate starvation was previously shown to be accompanied by the disappearance of four positioned nucleosomes from the promoter. To investigate the mechanism, we replaced the PHO80 gene, a negative regulator of PHO5, by a temperature-sensitive allele. As a consequence, PHO5 can be activated in the presence of phosphate by a temperature shift from 24 degrees C to 37 degrees C. Under these conditions, the promoter undergoes the same chromatin… CONTINUE READING
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