Nucleosides and nucleotides. 218. Alternate-strand triple-helix formation by the 3'-3'-linked oligodeoxynucleotides using a purine motif.

@article{Hoshika2003NucleosidesAN,
  title={Nucleosides and nucleotides. 218. Alternate-strand triple-helix formation by the 3'-3'-linked oligodeoxynucleotides using a purine motif.},
  author={Shuichi Hoshika and Yoshihito Ueno and Akira Matsuda},
  journal={Bioconjugate chemistry},
  year={2003},
  volume={14 3},
  pages={607-13}
}
In this paper, we describe the synthesis of the 3'-3'-linked TFOs that can form the antiparallel triplexes with the duplex DNA target by reverse Hoogsteen hydrogen bonds. Stability of the alternate-strand triplexes between these TFOs and the target DNAs was investigated using the electrophoretic mobility shift assay (EMSA). It was found that the alternate… CONTINUE READING