Nucleosides and nucleotides: natural bioactive substances in milk and colostrum

  title={Nucleosides and nucleotides: natural bioactive substances in milk and colostrum},
  author={Eckhard Schlimme and D. Mart{\'i}n and Hans Meisel},
  journal={British Journal of Nutrition},
  pages={59 - 68}
Nucleotides, nucleosides and nucleobases belong to the non-protein-nitrogen (NPN) fraction of milk. The largest amounts of ribonucleosides and ribonucleotides – ribose forms only were considered in this review – were measured directly after parturition in bovine milk and other ruminants as well as in the milk of humans. Generally, concentrations of most of the nucleos(t)ides tend to decrease gradually with advancing lactation period or nursing time. The species-specific pattern of these minor… 
Nucleotides and nucleosides in ovine and caprine milk during lactation.
The nucleoside and nucleotide content in ovine and caprine milks at the colostral, transitional, and mature stages of lactation was determined to identify the major NS and orotic acid contents did not differ significantly between the 2 species.
The role of dietary nucleotides in single-stomached animals
Suggestions are made for inclusion of nucleotides in the diet to benefit piglets' health and reduce the consequences accompanying early weaning.
A review on the nucleic acid constituents in mushrooms: nucleobases, nucleosides and nucleotides
This review provides a broad overview of the distribution of purine nucleobases (adenine and guanine); pyrimidine nucleOBases (cytosine, uracil, and thymine); nucleosides (uridine, guanosine, adenosine and cytidine); as well as novel nucleoside/tides in edible and nonedible mushrooms.
Nucleotides in canine colostrum and milk at different stages of lactation
The first report on the presence of nucleotides in canine milk is reported, and their occurrence could indicate a species-specific nucleotide metabolism or different secretory mechanisms.
Analysis of Nucleosides and Nucleotides in Milk and Infant Formula
iii ABSTRACT Nucleotides have been routinely supplemented to infant formulas due to the important roles they play in metabolism and to replicate the higher concentrations typically found in human
Screening of dietary nucleotides from natural sources for therapeutic uses
The screening of samples from different sources helped to determine the desirable concentration of nucleic acid in natural sources for dietary nucleotides, and investigation is in progress to study influence on animal model, developing therapeutic formulation and scale up criteria.
Dietetic nucleotides participate in cell division and growing, modulation of immunological system, and help maintaining intestinal health, reducing incidence of enteric diseases.


Total potentially available nucleosides of human milk by stage of lactation.
The total potentially available nucleosides (TPAN) of pooled and individual milk samples segregated by stage of lactation from 100 women in three European countries to test for effect of culture and diet and was predominantly present as monomeric and polymeric nucleotides.
Profile of nucleotides and nucleosides of human milk.
The results suggest that nucleosides and nucleotides found in human milk may play some important roles in the development of infants.
Nucleotides in infant nutrition
  • J. Boza
  • Medicine
    Monatsschrift Kinderheilkunde
  • 1998
The possible beneficial effects of dietary nucleotides on small intestine (maturation and recovery) and gut microflora, lipid and hepatic metabolism and on the immune system are discussed.
Ribonucleosides in Human Milk. Concentration Profiles of These Minor Constituents as a Function of the Nursing Time
Longitudinal studies have been carried out to determine the concentration profiles of the individual ribonucleosides in the milk of humans as a function of the nursing time, and it is known that nucleosides show a typical species-specific pattern.
Effect of Dietary Nucleosides on Growth and Maturation of the Developing Gut in the Rat
The pattern of change in disaccharidase activity suggests that DN may enhance gut growth and maturation of the intestine in the weanling rat, the effects being more pronounced in the proximal segment.
Ribonucleosides: Chemical parameters for controlling the heat treatment of milk
From experimental findings concerning changes in the contents of ribonucleosides - which belong to the group of minor milk constituents - in heat-treated milk it can be concluded that the
Metabolites of nucleic acids in bovine milk.
To investigate metabolites of nucleic acids in milk as by-products of protein biosynthesis, a method for determination of pyrimidine and purine compounds by reversed-phase high-pressure liquid
Ribonucleosides as minor milk constituents
The results of the longitudinal study have shown that — with the exception of the colostral phase — the levels of these minor constituents vary only slightly throughout lactation, implying that ribonucleosides are useful for characterizing milk of different species and technological treatment.
Effect of dietary nucleotides on the plasma fatty acids in at-term neonates.
Plasma polyunsaturated fatty acids with more than 18 carbons of the omega 6 family were significantly increased in infants fed with the nucleotide-supplemented milk formula with respect to those fed the milk formula, whereas no differences could be detected between the human milk-fed and theucleotide milk formula-fed ones.