Nucleoside transport in normal and neoplastic cells.

  title={Nucleoside transport in normal and neoplastic cells.},
  author={Judith A. Belt and Neyssa M Marina and Doris A. Phelps and Charles R. Crawford},
  journal={Advances in enzyme regulation},
The permeation of nucleosides across the plasma membrane of mammalian cells is complex and mediated by at least five distinct transporters that differ in their sensitivity to inhibitors and in their specificity for nucleosides. The basic properties and permeant specificity of these transporters are summarized in Table 3. It appears that there may be differences in the distribution of these transporters in tumors and normal tissues that might be exploited for chemotherapeutic purposes. The human… CONTINUE READING


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