Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.

@article{Paradkar2017NucleosideDM,
  title={Nucleoside diphosphate-linked moiety X-type motif 15 C415T variant as a predictor for thiopurine-induced toxicity in Indian patients.},
  author={Minal U Paradkar and Devendra C. Desai and Tester F. Ashavaid},
  journal={Journal of gastroenterology and hepatology},
  year={2017},
  volume={32 3},
  pages={620-624}
}
BACKGROUND AND AIM Interindividual variation seen in the thiopurine metabolism is attributed to the genetic variant in thiopurine methyltransferase (TPMT) gene leading to myelosuppression. In Asians, the thiopurine-induced toxicity is not completely explained by TPMT variants. Literature indicates that a newer genetic variant in nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) gene is associated with thiopurine intolerance. We aimed to determine the risk allele frequency of NUDT15… CONTINUE READING