Nucleoside diphosphate kinases (NDPKs) in animal development

@article{TakcsVellai2014NucleosideDK,
  title={Nucleoside diphosphate kinases (NDPKs) in animal development},
  author={Krisztina Tak{\'a}cs-Vellai and Tibor Vellai and Zsolt Farkas and Anil Mehta},
  journal={Cellular and Molecular Life Sciences},
  year={2014},
  volume={72},
  pages={1447-1462}
}
In textbooks of biochemistry, nucleoside diphosphate conversion to a triphosphate by nucleoside diphosphate ‘kinases’ (NDPKs, also named NME or NM23 proteins) merits a few lines of text. Yet this essential metabolic function, mediated by a multimeric phosphotransferase protein, has effects that lie beyond a simple housekeeping role. NDPKs attracted more attention when NM23-H1 was identified as the first metastasis suppressor gene. In this review, we examine these NDPK enzymes from a… CONTINUE READING
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