Nucleoside and Non-nucleoside IMP Dehydrogenase- Inhibitors as Antitumor and Antiviral Agents

  title={Nucleoside and Non-nucleoside IMP Dehydrogenase- Inhibitors as Antitumor and Antiviral Agents},
  author={Palmarisa Franchetti and Mario Grifantini},
  journal={Current Medicinal Chemistry},
IMP dehydrogenase (IMPDH) is an enzyme which catalyzes the NAD-dependent conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP) at the metabolic branch point in the de novo purine nljcleotide synthetic pathway. IMPDH was shown to be increased significantly in cancer cells and therefore considered to be a sensitive target for cancer chemotherapy. By blocking the conversion of IMP to XMP, IMPDH inhibitors lead to depletion of the guanylate (GMP, GDP, GTP and dGTP… 
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Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents.

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