Nucleoside and Non-nucleoside IMP Dehydrogenase- Inhibitors as Antitumor and Antiviral Agents

@article{Franchetti1999NucleosideAN,
  title={Nucleoside and Non-nucleoside IMP Dehydrogenase- Inhibitors as Antitumor and Antiviral Agents},
  author={Palmarisa Franchetti and Mario Grifantini},
  journal={Current Medicinal Chemistry},
  year={1999}
}
IMP dehydrogenase (IMPDH) is an enzyme which catalyzes the NAD-dependent conversion of inosine 5'-monophosphate (IMP) to xanthosine 5'-monophosphate (XMP) at the metabolic branch point in the de novo purine nljcleotide synthetic pathway. IMPDH was shown to be increased significantly in cancer cells and therefore considered to be a sensitive target for cancer chemotherapy. By blocking the conversion of IMP to XMP, IMPDH inhibitors lead to depletion of the guanylate (GMP, GDP, GTP and dGTP… 
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Nucleoside and non-nucleoside IMP dehydrogenase inhibitors as antitumor and antiviral agents.
TLDR
It was hypothesized that the inhibitory activity of tiazofurin is due to an attractive electrostatic interaction between the heterocyclic sulphur atom and the furanose oxygen 1 which constrain rotation about the C-glycosidic bond in tiaz ofurin and in its active anabolite TAD.