Nucleoside analogues and mitochondrial toxicity.

  title={Nucleoside analogues and mitochondrial toxicity.},
  author={Russell D Fleischer and Debra Boxwell and Kenneth E Sherman},
  journal={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  volume={38 8},
An evaluation of the US Food and Drug Administration's Adverse Event Reporting System identified that patients coinfected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity, including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis. In response, the US product… CONTINUE READING
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Risk factors for hepatic decompensation in cirrhotic patients with HIV-HCV coinfection treated with PEG interferon or interferon and ribavirin or placebo [abstract PL12.4

  • S Mauss, D Larrey, W. Valenti
  • 2002
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