Nucleoside analogues: mechanisms of drug resistance and reversal strategies

Abstract

Nucleoside analogues (NA) are essential components of AML induction therapy (cytosine arabinoside), effective treatments of lymphoproliferative disorders (fludarabine, cladribine) and are also used in the treatment of some solid tumors (gemcitabine). These important compounds share some general common characteristics, namely in terms of requiring transport… (More)
DOI: 10.1038/sj.leu.2402114

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