Nucleoside analogue-sparing strategy for the treatment of chronic HIV infection: potential interest and clinical experience.

@article{Joly2005NucleosideAS,
  title={Nucleoside analogue-sparing strategy for the treatment of chronic HIV infection: potential interest and clinical experience.},
  author={V. L. Joseph Joly and Patrick G Yeni},
  journal={Antiviral therapy},
  year={2005},
  volume={10 1},
  pages={29-40}
}
Nucleoside analogue-sparing antiretroviral combinations may be interesting as first-line therapies as they spare a complete class of drugs that will remain fully active for later use and prevent the risk of mitochondrial toxicity related to exposure to nucleoside reverse transcriptase inhibitors (NRTIs). This strategy is also used in patients failing NRTIs with cross-resistance to compounds in this class. Different combinations of antiretroviral drugs are theoretically available. Non-nucleoside… CONTINUE READING