• Corpus ID: 41269296

Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection.

  title={Nucleoside analogue-associated peripheral neuropathy in human immunodeficiency virus infection.},
  author={David M. Simpson and Michele Tagliati},
  journal={Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association},
  volume={9 2},
  • D. Simpson, M. Tagliati
  • Published 1 June 1995
  • Medicine, Biology
  • Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association
Peripheral nerve disorders are among the most common neurological complications of HIV disease. Distal sensory polyneuropathy (DSP) is the most common form of neuropathy in patients with AIDS and can be caused by diverse mechanisms, including infectious, metabolic, inflammatory, nutritional, and toxic factors. Antiretroviral agents may cause or contribute to HIV-related DSP. Recognition of peripheral neuropathy has become increasingly important as more patients receive nucleoside analogue… 
HIV-Associated Peripheral Neuropathy
Treatment of painful DSP is primarily symptomatic, while pathogenesis-based therapies are under investigation, and reduction or discontinuation of neurotoxic agents should be considered if possible.
Managing HIV peripheral neuropathy
The current treatment for HIV-associated DSP is symptomatic, with pain modifying medications, including anti-inflammatory agents, opioids, antidepressants, antiepileptics, topical anesthetics, and capsaicin.
Selected peripheral neuropathies associated with human immunodeficiency virus infection and antiretroviral therapy.
  • D. Simpson
  • Medicine, Biology
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  • 2002
The symmetrical forms of polyneuropathy that occur in association with HIV infection and nucleoside analogue therapy are reviewed along with a discussion of theories of pathogenesis and results of treatment to date.
HIV-Related Peripheral Nervous System Illness
This chapter addresses rare neuromuscular conditions that have been reported in HIV-infected patients including the demyelinating neuropathies, mononeuropathy multiplex, the diffuse infiltrative lymphocytosis syndrome, amyotrophic lateral sclerosis, and myopathy.
HIV neuropathy
The prevalence of those affected by HIV-DSP will continue to grow with the aging population of HIV-infected individuals, and clinicians often use off-label medications, including antidepressants, anticonvulsants, topical agents and other analgesics.
Peripheral Neuropathy with Nucleoside Antiretrovirals
Patients at increased risk of peripheral neuropathy should potentially avoid the use of the neurotoxic nucleoside analogues or be more carefully monitored during therapy.
There are several discrete types of HIV-associated neuropathy, which can be classified according to the timing of their appearance during HIV infection, their etiology and whether they are primarily axonal or demyelinating.
HIV neuropathy: Insights in the pathology of HIV peripheral nerve disease
HIV‐associated neuropathies have become the most frequent neurological disorder associated with HIV infection and the use of skin biopsy has become a useful tool in the evaluation of HIV‐N.
HIV Infection and the PNS
HIV is neuroinvasive and neurovirulent, but not necessarily neurotrophic, suggesting that most of the neurotoxicity of HIV infection is indirect and most likely mediated via chemokines, cytokines, or viral proteins released by the infiltrating macrophages.