Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1.

  title={Nucleoredoxin regulates glucose metabolism via phosphofructokinase 1.},
  author={Yosuke Funato and Tatsuya Hayashi and Yasuhiro Irino and Tadaomi Takenawa and Hiroaki Miki},
  journal={Biochemical and biophysical research communications},
  volume={440 4},
Phosphofructokinase (PFK) 1 is a glycolytic enzyme, and its abnormality contributes to the development of multiple human diseases, such as cancer. Here, we report that nucleoredoxin (NRX), a thioredoxin-related oxidoreductase, is a novel interacting partner of PFK1. NRX binds directly to PFK1, and endogenous NRX and PFK1 interact in vivo. In NRX(-/-) mouse embryonic fibroblasts (MEFs), the oligomerization status of PFK1 is altered and the catalytic activity of PFK1 is decreased. NRX deficiency… CONTINUE READING

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