Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).

@article{Hayashi2010NucleoredoxinNR,
  title={Nucleoredoxin negatively regulates Toll-like receptor 4 signaling via recruitment of flightless-I to myeloid differentiation primary response gene (88).},
  author={Tatsuya Hayashi and Yosuke Funato and Takeshi Terabayashi and Akifumi Morinaka and Reiko Sakamoto and Hirotake Ichise and Hiroyuki Fukuda and Nobuaki Yoshida and Hiroaki Miki},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 24},
  pages={18586-93}
}
We previously characterized nucleoredoxin (NRX) as a negative regulator of the Wnt signaling pathway through Dishevelled (Dvl). We perform a comprehensive search for other NRX-interacting proteins and identify Flightless-I (Fli-I) as a novel NRX-binding partner. Fli-I binds to NRX and other related proteins, such as Rod-derived cone viability factor (RdCVF), whereas Dvl binds only to NRX. Endogenous NRX and Fli-I in vivo interactions are confirmed. Both NRX and RdCVF link Fli-I with myeloid… CONTINUE READING

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