Nucleoprotein transitions during spermiogenesis in mice with transition nuclear protein Tnp1 and Tnp2 mutations.

@article{Zhao2004NucleoproteinTD,
  title={Nucleoprotein transitions during spermiogenesis in mice with transition nuclear protein Tnp1 and Tnp2 mutations.},
  author={Mingming Zhao and Cynthia R. Shirley and Suzanne Mounsey and Marvin L. Meistrich},
  journal={Biology of reproduction},
  year={2004},
  volume={71 3},
  pages={1016-25}
}
Chromatin remodeling during spermiogenesis is characterized by a series of nuclear protein replacements. Histones are replaced by transition nuclear proteins, which are in turn replaced by protamines. The transition nuclear proteins, TP1 and TP2, and the protamines, PRM1 and PRM2, are the major nuclear proteins involved in this process. Biochemical studies of mice with null mutations in one of the Tnp genes showed that the absence of one TP led to an apparent elevation in the amount of the… CONTINUE READING

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