Nucleoporin-mediated regulation of cell identity genes.

  title={Nucleoporin-mediated regulation of cell identity genes.},
  author={Arkaitz Ibarra and Chris Benner and Swati Tyagi and Jonah Cool and Martin W Hetzer},
  journal={Genes & development},
  volume={30 20},
The organization of the genome in the three-dimensional space of the nucleus is coupled with cell type-specific gene expression. However, how nuclear architecture influences transcription that governs cell identity remains unknown. Here, we show that nuclear pore complex (NPC) components Nup93 and Nup153 bind superenhancers (SE), regulatory structures that drive the expression of key genes that specify cell identity. We found that nucleoporin-associated SEs localize preferentially to the… CONTINUE READING
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