Nucleoplasmic calcium regulation in rabbit aortic vascular smooth muscle cells.

@article{Abrenica2003NucleoplasmicCR,
  title={Nucleoplasmic calcium regulation in rabbit aortic vascular smooth muscle cells.},
  author={Bernard Abrenica and Grant N Pierce and James S. C. Gilchrist},
  journal={Canadian journal of physiology and pharmacology},
  year={2003},
  volume={81 3},
  pages={301-10}
}
In this study, we investigated whether nucleoplasmic free Ca2+ in aortic vascular smooth muscle cells (VSMCs) might be independently regulated from cytosolic free Ca2+. Understanding mechanisms and pathways responsible for this regulation is especially relevant given the role of a numerous intranuclear Ca2+-sensitive proteins in transcriptional regulation, apoptosis and cell division. The question of an independent regulatory mechanism remains largely unsettled because the previous use of… CONTINUE READING
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